My Author Bio with BlueCat Screenplay Review & Private Detective Frederick Falloy Novel Reviews

Sheila Bitts, MFA, MPH aka Sheila Mae Bitts, MFA, MPH
Current focus: Prose/Movie Screenplay
Entanglement (2022) can be read as a standalone. It's the second novel in the Frederick Falloy Private Detective Novels. My screenplay called, The Diamond Escape (2020), is based on my novel of the same name (2017). It is the first novel of the Frederick Falloy Private Detective Series.
Additional publications: Roses (2018, Anniversary Edition Poetry), Worth (2022, Short Stories).


BlueCat Review of Screenplay, "The Diamond Escape"

"This script is entertaining and is clearly inspired by many classic movies. It’s both a heist story and a detective story and the writer draws deftly from both genres to create a breakneck pursuit of the titular diamonds. In this expansive chase... The diversity of place and the speed with which we move between settings create an exciting and, on the whole, original piece within two genres that crave originality."

"Falloy is a newly minted private eye who I can root for."

"The piece appears to be well-researched and raises many important questions regarding the theft of jewels and artifacts from around the world on behalf of colonial interests."

"There is a richness within the setting, especially the scenes set in the museum; the writer is familiar with all the characters we might encounter within these academic circles and creates a power around them, specifically with Etienne and Leon. This mix of the characters’ wealth and intellectualism make Etienne and Leon particularly formidable and interesting."

"On the whole, an exciting piece that grapples with many important questions and draws us through a heist while keeping our interest, certainly no small feat... (There is a) ...nice touch at the end, which ties the story in a circle and is thematically very satisfying..."

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The Diamond Escape (novel) by Sheila Bitts Review by Liz Konkel for Readers’ Favorite: "witty and gritty"
"Sheila Bitts is case orientated in her style, with vivid details and a thrilling mystery. The case is compelling with an underlying commentary, diamonds, and hope for a better tomorrow. The banter between the characters is quick and witty...The Diamond Escape brings strong prose and layered characters to life in this gritty detective story."

The Diamond Escape (novel) by Sheila Bitts 
5/5 Stars
#mystery #heist #privatedetective #frederickfalloy #novel #thriller #mysterybooks #noir
Review by Natalie Soine for Readers’ Favorite
"As a South African, I found The Diamond Escape particularly interesting. Sheila Bitts created a remarkable story around the Marikana event and certainly has a vivid imagination. I enjoyed the originality of the plot and the fast pace. There are many interesting characters from past to present who all make the story more exciting and believable. The scenes are well-described, including the museum, which does exist and includes a what-if scenario. Sheila also added a few twists and turns that all keep the reader interested. I look forward to reading more books by this incredible author and am giving this tale a well-deserved five stars."

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The Diamond Escape (novel) by Sheila Bitts 
5/5 Stars
Review by Alma Boucher for Readers’ Favorite
"The Diamond Escape is engaging and exciting. The events are described in detail, and it was easy to visualize the people and events. The plot is complex...(the) tension built as the story progressed and kept me on the edge of my seat. The story was fast-paced and jam-packed with action. There was never a dull moment. Sheila Bitts builds the background for a wide number of characters. It was a wild roller coaster ride with participants that were authentic and relatable. Each had a unique personality trait. The story was well written, and mystery and suspense were blended. The twists and turns unraveled toward an excellent ending. It was unexpected and surpassed my expectations."

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The Diamond Escape (novel) by Sheila Bitts 
5/5 Stars
Review by K.C. Finn for Readers' Favorite
"The Diamond Escape is filled with mystery, suspense, and adventure. It is best suited to the general adult reading audience and was penned by Sheila Bitts. (She) has crafted a concise and intense thriller that will certainly please readers looking to escape into an interesting and atmospheric tale...I loved the way that the setting played such a key role in how the plot unfolded and in creating a varied atmosphere of museum culture versus the seedy urban crime underworld. I also enjoyed the character development, especially the inclusion of Gail. Her subtle role grows as the plot progresses...I would highly recommend The Diamond Escape to mystery fans everywhere who are seeking a great new detective series to enjoy."

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(Novel #2 in the Falloy Private Detective Series)
Entanglement (novel) by Sheila Bitts Review by Pikasho Deka for Readers' Favorite
"Sheila Bitts takes us on a wild ride with the second installment of the Falloy Private Detective Novels series...I enjoyed the dynamic between Falloy and Snow, as well as the twists and turns of the plot that kept me hooked to the pages. Recommended to sleuth mystery lovers."

Entanglement (novel) by Sheila Bitts
 5/5 Stars
Review by Alma Boucher for Readers' Favorite
"Entanglement continues the Falloy detective series. Sheila Bitts took me on a rollercoaster ride of mystery, murder, and suspense. The author's imagination had me hooked from the start. The plot was intriguing and complicated, and I could not put it down. It was a page-turner and full of action.
The character development was brilliant. There were many players, and it was exciting to get to know them. My favorite characters were Falloy and Snow. The energy between them was fun and lightened the seriousness of the circumstances precipitated by the danger and murders. The story was well-written and exceeded my expectations by far."

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Entanglement (novel) by Sheila Bitts 
5/5 Stars
Review by K.C. Finn for Readers' Favorite
"Entanglement is a work in the mystery, crime, and suspense subgenres, forming the second installment in the Falloy Private Detective series. Penned by Sheila Bitts, it is best suited to the general adult reading audience. In this fantastic continuation of the exploits of PI Frederick Falloy, we find ourselves in 2019 for the next case, where Falloy is tasked with the protection of Hollywood starlet Snow. As Russian espionage sweeps the underbelly of Chicago, Snow's connections to a federal congressman and the aspiring presidential candidate only add more danger and drama to Falloy's life as he tries to unpick a web of secrets, murder, and stardom.
Sheila Bitts has developed another fantastic case in the Frederick Falloy casebook, which is even more intricately plotted and deeply developed than the last. Although these mysteries are concise and can easily be enjoyed in a single cozy binge-read, the level of plot, detail, and emotional gravitas is expertly penned to keep you hooked and have you thinking about the consequences of the drama and corruption long after you've set the book down...Chicago again makes for a gorgeous backdrop against which much of the dynamism of the story takes place. Overall, I would highly recommend continuing your mystery journey with Entanglement as soon as possible."

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Entanglement (novel) by Sheila Bitts 
5/5 Stars
Review by: Essien Asian of Readers' Favorite. 
"Sheila Bitts employs creative conversations between her characters to set the tone for her mystery novel and dictate the pace in a manner that maintains our curiosity right up to the final chapters. 
Entanglement has an exciting cast of characters with backstories that would fit any story. However, that is where the typical ends in this enterprising piece of work. Bitts' inclusion of time-altering scientific concepts in a story equally heavy on drama and old-school espionage activity creates an immersive atmosphere that sucks in even the most reluctant reader with a subtlety that should be applauded. 
An even balance between the physical tussling and the deduction-related activity guarantees that the avid action junkie’s essential diet is satisfied in a delicious potpourri of spine-tingling suspense. An impressive novel by my standards. It will surely hold its own in the genre."

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Poem: What’s Got Into You?

April #NationalPoetryMonth a revised poem from my first edition book: Collected Poems 1988-2008. I did not publish this revision in Roses (2018), however.

What’s Got Into You?

When cars line up at
5 –Friday
6, 7 o’clock?
orchestrated start and
beep-crash-chaos?

A janitor’s vacuum
–office space–

‘Cause you become where you are
at the window,
reflecting old age when young.

To see past one’s own reflection,
listen to my exo-spection:
I’ve got complete control of the airwaves.
(every bike messenger’s radio squawks simultaneously)

It’s a mess out there tonight/but the work clock’s stoppin’
and the weather’s just right/so push those petals and pull
that GO light/ cause when you open your eyes, it’ll be home in sight!

Like the sun,
Bending knees, cycling home
on your own

Your yodel or wink
Casts pink on gray marble
as strange as fog in August:

EVERYTHING A MONET:
Standard Oil–a Water-Lily.
Art Institute–a Stack of Hay.

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–Sheila Mae Bitts circa 1991/ revised 4/20/2023

Frederick Falloy Private Detective Novels by Sheila M. Bitts

#mystery #novels #privatedetective #spythrillers #thrillers #thriller #heist #spythriller #privatedetectiveseries #privatedetectivenovels #crime #Chicago #noir #literary #conspiracy #science #physics #art #artists #assassins #homicide

Review of The Diamond Escape (novel by Sheila Bitts)

“Reviewed by Liz Konkel for Readers’ Favorite

4/5 Stars

“The Diamond Escape by Sheila Bitts opens in 2012 at a diamond mine in South Africa, where Frederick Falloy was working as a reporter. Two years later, Frederick is working as a private detective on a case for stolen Cacaw Diamonds. The case takes a turn when the thief turns to murder, and the evidence starts piling up. Everyone close to Frederick seems likely to be a suspect, with time running out before the diamonds are gone. As he works with officer Phillip Grable, he builds a surprising friendship, and finds romance where he least expects it.

“Sheila Bitts is case orientated in her style, with vivid details and a thrilling mystery. Several suspects create twists and turns as Frederick and Grable take one piece of the puzzle after the next. The case is compelling with an underlying commentary, diamonds, and hope for a better tomorrow. The banter between the characters is quick and witty, with Frederick’s dialogue changing slightly, depending on who he’s addressing. He goes from flirty to snarky within lines, bringing charm, attitude, and heart to the story. A bit of romance between Frederick and Gail touch on the softer side of the case, creating potential new beginnings and chances at a happy ending. Gail is a complicated character, but I like that she’s a strong woman who can defend herself and her baby. She’s very elegant and sophisticated, and strikes a balance with Frederick. The Diamond Escape brings strong prose and layered characters to life in this gritty detective story.”

#mystery #novels #privatedetective #spythrillers #thrillers #thriller #heist #spythriller #privatedetectiveseries #privatedetectivenovels #crime #Chicago #noir #literary #blooddiamonds

https://readersfavorite.com/book-review/the-diamond-escape

Review of Entanglement (novel by Sheila Bitts)

Entanglement by Sheila Bitts Reviewed by Pikasho Deka for Readers’ Favorite

4/5 stars

“Entanglement is a mystery thriller story by Sheila Bitts. Snow is a Hollywood actress who unwittingly finds herself tangled in a chaotic mess when a seemingly random stranger hands her a mysterious package, only to be killed soon after by Russian spies. She seeks the help of Private Detective Frederick Falloy, who offers her sanctuary and protection. But, suspecting links to other murders in the city, Falloy follows the clues to a drop site, inadvertently embroiling himself in a larger conspiracy that puts his own life and that of his friends in mortal danger. Meanwhile, Snow’s friend Zelda is married to the Republican congressman from Illinois, Kurt Zoeller, a presidential candidate. Zoeller has his grand plans for America, but after events escalate further in one of Zoeller’s rallies, Falloy must somehow get to the bottom of the mystery.

“Sheila Bitts takes us on a wild ride with the second installment of the Falloy Private Detective Novels series. Entanglement is a mystery thriller with an intricate plot and a large cast of characters. Bitts uses a lot of quick scene cuts and POV switches, which makes the narrative, at times, feel almost surreal. There are a lot of underlying layers behind some of the dialogue and scenes, which makes for an atmosphere filled with tension and intrigue that is immersive and thoroughly absorbing to read. I enjoyed the dynamic between Falloy and Snow, as well as the twists and turns of the plot that kept me hooked to the pages. Recommended to sleuth mystery lovers.”

https://readersfavorite.com/book-review/entanglement/1?fbclid=IwAR2_P6c-pz54WjG950-0rgjKI4zVfKLyxlpTVcb4KoGRFs8yRhOXgeOfJNs

BlueCat Review of my screenplay based on my novel, The Diamond Escape

BlueCat Review of Screenplay, “The Diamond Escape”

“This script is entertaining and is clearly inspired by many classic movies. It’s both a heist story and a detective story and the writer draws deftly from both genres to create a breakneck pursuit of the titular diamonds. In this expansive chase.. The diversity of place and the speed with which we move between settings create an exciting and, on the whole, original piece within two genres that crave originality.”

“Falloy is a newly minted private-eye who I can root for.”

“The piece appears to be well-researched and raises many important questions regarding the theft of jewels and artifacts from around the world on behalf of colonial interests.”

“There is a richness within the setting, especially the scenes set in the museum; the writer is familiar with all the characters we might encounter within these academic circles and creates a power around them, specifically with Etienne and Leon. This mix of the characters’ wealth and intellectualism make Etienne and Leon particularly formidable and interesting.”

“On the whole, an exciting piece that grapples with many important questions and draws us through a heist while keeping our interest, certainly no small feat… (There is a)…nice touch at the end, which ties the story in a circle and is thematically very satisfying…”

Quarantine on a Cruise Ship

USA Laws on Quarantine

According to the Center for Disease Control and Prevention (CDC, 2014), the Commerce Clause of the U.S. Constitution section 361 of the Public Health Service Act (42 U.S. Code § 264), empowers the U.S. Secretary of Health and Human Services (HHS) with the authority to prevent the entry and spread of communicable diseases not only from state to state, but also from foreign countries into the United States. The Federal HHS gives power to the CDC (2014) under 42 Code of Federal Regulations parts 70 and 71 “to detain, medically examine, and release persons arriving into the United States and traveling between states who are suspected of carrying these communicable diseases;” this includes cruise ship passengers and crew to find the cause of the illness.

Logistics on a Medical Tourist Cruise Ship?

Quarantine and public health interventions as it relates to cruise ship passengers’ issues may have some effectiveness because there are cabins for the customers. If each person had his or her own cabin when it comes to isolation, the sick could be isolated. If the disease is air-borne, there would need to be proper ventilation in place for the isolated and perhaps the area would need to be sectioned off from the rest of the ship to provide the best ventilation. The CDC (2017) has a Vessel Sanitation Program empowered by the Public Health Service Act (42 U.S.C. Section 264 Quarantine and Inspection Regulations to Control Communicable Diseases) with specific CDC (2010) site to check different cruise lines scores. Breaking a quarantine is a criminal misdemeanor and the laws are enforced by local, state, federal, and tribal authorities according to the CDC (2014). Sometimes, passengers travel for medical tourism. In this situation, the passenger would need to be cleared to travel to the foreign country to receive treatment. If a traveler went to India to receive a cheaper treatment, Petersen & Mohsin (2016) ask should that patient/passenger be screened for multi-resistant strains of bacteria?

International Cruise Ships and Refugees

According to the World Health Organization (WHO, 2017), a 2005 document called the IHR provides the foundation for the legal basis for the health documentation necessary for international travelers and for the safe “transport and sanitary protections for the users of international airports, ports, and ground crossings.” The third edition of the International Health Regulation (IHR, 2005), added on July 11, 2016, includes the World Health Assembly resolution WHA58.3, which is about a “period of protection of vaccination against yellow fever.” If there were travel restrictions and travel bans from areas where disease transmission is high, these would not be boarding a cruise ship, unless a Greek cruise ship were to pick-up Syrian refugees whose boats may have capsized, for example. Those saved may be likely quarantined even if yellow fever is not endemic to Syria due to the size and nature of a cruise ship experience expectations of hygiene, health, and customer service considerations. Regardless, the international and interstate rules on travel restrictions and the Ethics of all Passenger’s Rights to Know would have to be followed.

Safety, Ethics, and Keeping Passengers Informed 

On a cruise ship, there is usually one large cafeteria and maybe some smaller bars and snack shops. All the food service would have to be carefully controlled along the quarantine and isolation regulations. Control of communicable disease could be efficient as it would not take very long to de-board all other passengers not under quarantine or isolation.  Resources at stops along the cruise could be easily requested besides any in-house medical team that may distribute personal protective equipment as well. Issues some cruise passengers would have if there were a travel restriction would be the discomfort on their vacation at the very least. Customer service would need to be included in the quarantine and isolation requests.  Ethically, the whole ship would need to know their risks and the reason for the isolation and quarantine situations. For example, in Turkey, 2016, at a land tourist site there were suicide bombers according to Gonzalez & Lipman (2016). Making sure cruise passengers know their safety is secure is important besides making sure a disease in under control.

Sheila Bitts is a graduate student in Public Health at American Public University System, a poet, novelist, and an APUS 3MT Finalist for 2017.

Supporting Citation/References

CDC. (2014, October 8). Quarantine and Isolation. Legal Authorities for Isolation and Quarantine. https://www.cdc.gov/quarantine/aboutlawsregulationsquarantineisolation.html

CDC. (2010, January 6). Vessel Sanitation Program (Cruise Line). Advance Cruise Lone Inspection Search. Scores. https://wwwn.cdc.gov/InspectionQueryTool/InspectionSearch.aspx

CDC. (2017, June 28). Vessel Sanitation Program. https://www.cdc.gov/nceh/vsp/default.htm

Gonzalez, V. V., & Lipman, J. K. (2016). Tours of Duty and Tours of Leisure. American Quarterly. 68(3). (pp. 507-521).

Petersen, E., & Mohsin, J. (2016). Should Travelers Be Screened for Multi-Drug Resistant (MDR) Bacteria after Visiting High Risk Areas Such as India? Travel Medicine and Infectious Disease. 14(6). (pp. 591-594).

World Health Organization. (2016).  International Health Regulations (2005), 3rd edition.  https://edge.apus.edu/access/content/group/1997db15-1275-f9c5-b052-e3f6f6c9ef26/Lessons/Week%205/WHO%20IHR.pdf

Retrospective on Ebola: Mitigation Blog

To the UN Executive Board and Advisory Committee: My student Blog Retrospective on Ebola

Sheila Bitts

American Public University System

July 16, 2017

Mitigation Blog

The West African Ebola Outbreak of 2013-2015: What Should Have Been Done?

The Protection of the United States and Other WHO Member States

At an August 8^th, 2014 press conference in Geneva, Keiji Fukuda, the World Health Organization (WHO)’s assistant director general for health security and environment, located the Ebola “hotspot” as centered in Guinea, Liberia, and Sierra Leone where the borders meet as reported by Hawkes (2014).  Chan, the WHO director general, convened a two-day meeting held by the WHO emergency committee teleconference where the group proclaimed the outbreak as “a public health risk to other states” although no travel ban was implemented as per Hawkes (2014) who added that Chan did however call for those exiting the countries involved to be monitored for 21 days, as the incubation period ranges greatly from 2 to 21 days.

United States Quarantine Policy

Lee (2016) explains, that in the US, the Public Health Accreditation Board (PHAB) only approves of health departments that have a public health ethics board to discuss and deliberate the intervention among stakeholders.  The Center for Disease Control and Prevention (CDC, 2003) in the United States, orders that the communicable diseases which require isolation and quarantine are authorized through a Presidential executive order to control: “cholera, diphtheria, infectious tuberculosis, plague, smallpox, yellow fever, viral hemorrhagic fevers,” and lastly, “severe acute respiratory syndrome (SARS),” which was added in April 2003.

The Zaire Ebola Virus as the Cause of the Epidemic

The Ebola Virus Zaire strain, which first appeared in the 1970s, was the “causative agent” of the outbreak which had about a 60% mortality rate, historically, but had a wider area of infection according to Hawkes (2014), who explained that Fukuda discouraged “large gatherings of people” at the hotspot area.  Chan conceded that techniques for containing Ebola’s spread were known, but that it was difficult to implement them in practice, because the areas involved had recently been fighting civil wars, and Hawkes (2014) further explained that Chan welcomed the help of  The World Bank and Médecins Sans Frontières, but knew the African weak medical infrastructure would be overwhelmed, therefore compelling Chan to convince the hotspot areas to shift into “urgent mode” and provide security for health workers as well, but this was to no avail.

The Epidemic Spreads

Initially, the WHO made their declaration in August 2014, when only Guinea, Liberia, Sierra Leone, and Nigeria had roughly 1779 cases with 961 deaths, as per Hawkes (2014), but by Mid-September 2014, the outbreak had spread to five countries in West Africa (Senegal), with approximately 4507 confirmed cases of Ebola, with 2296 deaths according to Team (2014).

Non-Compliance with Quarantine

Non-compliance with many of the African public health restrictions was pervasive.  In a recent publication in Social Science & Medicine, Blair, Morse & Tsai (2017) surveyed Liberian respondents who replied to the questionnaires expressing more distrust in the Liberian government if they had hardships.  Valeri, Patterson-Lomba, Gurmu, Ablorh, Bobb, Townes & Harling (2016) reported that the White regions reported no Ebola cases during the whole study period.

More Educated, The More Money to Bribe?

At the end of the study, Valeri et al (2016) were eventually led to the conclusion that education level did not mean more compliance during the outbreak according to their study on the sociological data from the whole region involved in the Ebola Virus Disease African epidemic of 2013-2015.  In fact, Valeri et al (2016) found that the “more educated areas of Guinea, Liberia and Sierra Leone had more severe Ebola outbreaks as measured by speed of epidemic growth and final epidemic size.”  The fastest growth rates of Ebola affected three capital cities: Conakry, Guinea; Monrovia, Liberia; and Freetown, Sierra Leone according to Valeri et al (2016), which are the same ones with the highest average education levels.  According to Pellecchia, Crestani, Decroo, Van den Bergh & Al-Kourdi (2015), it was common for people to bribe the burial teams for a burial in a private cemetery and to have funeral services at the funeral homes, defying the Liberian government’s cremation order interpretation of Fukuda’s WHO orders to show precaution regarding funerary practices.  In Social Science & Medicine, Blair’s (2017) Liberian questionnaire respondents who expressed non-compliance most likely did not trust the Liberian government even if the WHO was the initial messenger.

WHO Had Asked for Ethical Guidance

Knowing that this situation would have complicated dynamics from the beginning, according to Hawkes (2014), Marie-Paule Kieny, the WHO assistant director general, is quoted as saying in 2014, “We are in an unusual situation in this outbreak.  We have a disease with a high fatality rate without any proven treatment or vaccine.  We need to ask the medical ethicists to give us guidance on what the responsible thing to do is.”  Public health Ethicist Lee (2016) asks us to consider what we should do.  For example, Pellecchia et al (2015) explains that there was not only inconsistency in food distribution for those in the Liberian quarantine, but also stigma and hostility between the citizens and the government since the local leaders were not invited to the decision-making forums and no spiritual leaders were consulted, although they were essential for the affected communities.  Knowing that burial and cremation values conflict, citizens affected needed representation to safely and legally resolve the conflict without resorting to military violence. Otherwise, with such distrust due to health inequities, the public beneficence is not present nor authentic for the community involved; the WHO should have intervened to negotiate for inclusiveness for there to have been justice. The result could have saved more lives.

 

Tags: Public Health Ethics, Ebola, West Africa, Mitigation, Preparedness, Response, World Health organization (WHO), Center for Disease Control and Prevention (CDC), Community Engagement, Quarantine

Sheila Bitts is a graduate student in Public Health at American Public University System, a poet, novelist, and an APUS 3MT Finalist for 2017.

Ebola Vaccine Progress WHO Update: http://www.who.int/mediacentre/news/releases/2016/ebola-vaccine-results/en/

 

Supporting Citation Links/References

Blair, R. A., Morse, B. S., & Tsai, L. L. (2017, January). Public Health and Public Trust: Survey Evidence from The Ebola Virus Disease Epidemic in Liberia. Social Science & Medicine. 172. (pp. 89-97). http://www.sciencedirect.com/science/article/pii/S0277953616306256

CDC. (2003. April 4). Executive Order 13295: Revised List of Quarantinable Communicable Diseases: Former President George Bush. https://www.cdc.gov/sars/quarantine/exec-2004-04-03.html

Hawkes, N. (2014, August 9). Ebola Outbreak Is a Public Health Emergency of International Concern, WHO Warns. BMJ. 349: g5089. http://www.bmj.com/content/349/bmj.g5089

Lee, L.M. (2016, October 19). Ethics and Decision Making in Public Health October 2016. bioethicsgov. https://www.youtube.com/watch?v=pMLCgekjTDw&feature=youtu.be

Pellecchia, U., Crestani, R., Decroo, T., Van den Bergh, R., & Al-Kourdi, Y. (2015). Social Consequences of Ebola Containment Measures in Liberia. PloS one. 10(12). e0143036. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143036

Team, W. E. R. (2014, October 16). Ebola Virus Disease in West Africa—The First 9 Months of The Epidemic and Forward Projections. N Engl J Med. 2014(371). (pp. 1481-1495). http://www.nejm.org/doi/full/10.1056/NEJMoa1411100#t=article

Valeri, L., Patterson-Lomba, O., Gurmu, Y., Ablorh, A., Bobb, J., Townes, F. W., & Harling, G. (2016, October 12). Predicting Subnational Ebola Virus Disease Epidemic Dynamics from Sociodemographic Indicators. PLoS One. 11(10). doi: http://dx.doi.org.ezproxy2.apus.edu/10.1371/journal.pone.0163544 supporting citation link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163544